Concomitant utilization of benzodiazepines, including diazepam, and opioids may end in profound sedation, respiratory melancholy, coma, and Dying; reserve concomitant prescribing of benzodiazepines and opioids for use in patients for whom option cure alternatives are insufficient; cut down opiate dose one particular-3rd when diazepam is included

Drugs that have constraints apart from prior authorization, amount limits, and action therapy connected to Just about every prescription.

Scopolamine could potentially cause drowsiness, disorientation, and confusion; discontinue therapy if symptoms or indications of cognitive impairment produce; if, Even with this, indications persist in the intense type, instruct patients to seek professional medical attention; elderly and pediatric sufferers can be far more delicate to neurological and psychiatric results; consider more Repeated monitoring all through therapy in aged affected person

diazepam will raise the stage or outcome of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

diazepam will raise the degree or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A substrate) with weak CYP3A inhibitors is unavoidable, decrease to, or continue on lonafarnib at beginning dose.

Steer clear of or Use Alternate Drug. Stay away from coadministration of sensitive CYP3A4 substrates with ivosidenib or change with alternate therapies. If coadministration is unavoidable, check patients for loss of therapeutic effect of these drugs.

Monitor Carefully (one)crofelemer will increase over here amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the probable to inhibit CYP3A4 at concentrations envisioned within the gut; not likely to inhibit systemically simply because minimally absorbed.

Agents by having an effect on hepatic cytochrome P450 pathways or conjugation can alter the rate of diazepam metabolism. These interactions would be expected for being most vital with extended-expression diazepam therapy, as well as their medical significance is variable.[28]

primidone will lower the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

Comment: Coadministration of anticholinergic drugs and glucagon enhance the hazard of gastrointestinal adverse reactions as a result of additive outcomes on inhibition of gastrointestinal motility. .

diazepam increases amounts of lomitapide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Lomitapide dose mustn't exceed thirty mg/day.

dasatinib will increase the level or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

diazepam and daridorexant equally maximize sedation. Modify Therapy/Check Carefully. Coadministration improves danger of CNS melancholy, which may result in additive impairment of psychomotor efficiency and result in daytime impairment.

There are already postmarketing reports of coma and Loss of life with coadministration of buprenorphine and benzodiazepines. In several, although not these scenarios, buprenorphine was misused by self-injection. If a benzodiazepine should be employed for a sign in addition to seizures, lower the benzodiazepine Preliminary dose and cautiously titrate to clinical reaction.